The creation of a scientifically based Food Safety Management System called Hazard Analysis and Critical Control Points (HACCP) by The National Aeronautics and Space Administration (NASA) and others in 1960’s ushered a new era in food safety and quality. The Food Safety Modernization Act (FSMA) of 2011 expanded the concept to apply to other products. The HACCP system was designed for astronauts and now is globally recognized by governments, academia and industries. HACCP was created as a process centric system and from the beginning was a perfect system to apply statistical process control to eliminate, prevent or reduce deviation, faults, failure and variations. The National Advisory Committee on Microbiological Criteria for Foods (NACMCF), who wrote seven principles of HACCP, defines “Criterion as a requirement on which a judgement or decision can be based. Control is defined as (a) To manage the conditions of an operation to maintain compliance with established criteria. (b) The state where correct procedures are being followed and criteria are being met. Critical Control Point is a step at which control can be applied and is essential to prevent or eliminate a food safety hazard or reduce it to an acceptable level. Control Measure is any action or activity that can be used to prevent, eliminate or reduce a significant hazard. NACMCF also defines Critical Limit as a maximum and/or minimum value to which a biological, chemical or physical parameter must be controlled at a CCP to prevent, eliminate or reduce to an acceptable level the occurrence of a food safety hazard. Critical limits may be based upon factors such as temperature, time, physical dimensions, humidity, moisture level, water activity (aw), pH, titratable acidity, salt concentration, available chlorine, viscosity, preservatives, or sensory information such as aroma and visual appearance. Critical limits must be scientifically based. The critical limits and criteria for food safety may be derived from sources such as regulatory standards and guidelines, literature surveys, experimental results, and experts.” The integration of HACCP, FSMA, and Food Statistical Process Control (SPC) is a powerful tool to achieve established criteria to enhance food safety and quality, increase efficiency, reduce deviation, fault, failure and to make a lean system that is sustainable. This course is designed to achieve all the above.